2020 |
Ayako Nakamura-Ishizu, Shah Adil Ishtiyaq Ahmad, ToshioSuda. Bone Marrow Transplantation Dynamics: When Progenitor Expansion Prevails. Trends in Cell Biology. Sept 10 2020. doi.org/10.1016/j.tcb.2020.08.006
Ayako Nakamura-Ishizu, Keisuke Ito and Toshio Suda. Hematopoietic stem cell metabolism during development and aging. Developmental Cell. 2020 Accepted Matsumura T, Nakamura-Ishizu A, Muddineni SSNA, Tan DQ, Wang CQ, Tokunaga K, Tirado-Magallanes R, Sian S, Benoukraf T, Okuda T, Asou N, Matsuoka M, Osato M, Suda T. Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia. Blood. 2020 Jun 23:blood.2019004292. doi: 10.1182/blood.2019004292. Online ahead of print. O'Neill A, Chin D, Tan D, Abdul Majeed AQBB, Nakamura-Ishizu A, Suda T. Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential. Haematologica. 2020 Jun 11:haematol.2019.241406. doi: 10.3324/haematol.2019.241406. Online ahead of print. Endoh M, Baba M, Endoh T, Hirayama A, Nakamura-Ishizu A, Umemoto T, Hashimoto M, Nagashima K, Soga T, Lang M, Schmidt LS, Linehan WM, Suda T. A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity. Cell Rep. 2020 Feb 11;30(6):1823-1834.e5. doi: 10.1016/j.celrep.2020.01.042. |
2019 |
Takihara Y, Nakamura-Ishizu A, Tan DQ, Fukuda M, Matsumura T, Endoh M, Arima Y, Chin DWL, Umemoto T, Hashimoto M, Mizuno H, Suda T. High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells. Blood Adv. 2019 Aug 13;3(15):2323-2327.
Nakamura-Ishizu A, Suda T. Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation. Ann N Y Acad Sci. 2019 Jul 10. Nakamura-Ishizu A, MacArthur BD, Suda T. Beginning of a New Era: Mapping the Bone Marrow Niche. Cell. 2019 Jun 13;177(7):1679-1681. Matsumura T, Nakamura-Ishizu A, Takaoka K, Maki H, Muddineni SSNA, Wang CQ, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M, Suda T. TUBB1 dysfunction in inherited thrombocytopenia causes genome instability. Br J Haematol. 2019 Jun;185(5):888-902. Nakamura-Ishizu A, Suda T. Dynamic Changes in the Niche with N-Cadherin Revisited: The HSC "Niche Herein". Cell Stem Cell. 2019 Mar 7;24(3):355-356. Tan DQ, Li Y, Yang C, Li J, Tan SH, Chin DWL, Nakamura-Ishizu A, Yang H, Suda T. PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. Cell Rep. 2019 Feb 26;26(9):2316-2328.e6. Jiang Chen, Dan G. Duda, Aya Matsui, Hiroto Kikuchi, Kazumichi Kawakubo, Shuji Kitahara*. A basic and clinical perspective on the future or perioperative therapy for gastric cancer. Surg. Gastroenterol. Oncol. 2019 (in press) *Corresponding author Kohei Shigeta*, Meenal Datta*, Tai Hato*, Shuji Kitahara*, Ivy Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Peigen Huang, Andrew Zhu, Mark Cobbold, Rakesh Jain, and Dan G, Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC, Hepatology. 2019 (in press) *Co-first author Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L Flanary, Annmarie Ramkissoon, Lionel M.L. Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric Holland, William H. Yong, Craig Horbinski, Ichiro Nakano, Ralph J. DeBerardinis, Robert M. Bachoo, Paul S. Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff and Atsuo T. Sasaki. IMP dehydrogenase-2 drives aberrant nucleolar activity and structure in glioblastoma. Nat. Cell Biol . 2019: 21(8):1003-1014. Shuji Kitahara and Yasuhiro Suzuki, Does anti-vascular therapy reprogram the immunosuppressive microenvironment in gastric cancer? J Tokyo Wom Med Univ. 89: E100-E109, 2019 Asuka Yoshii Hisashi Ueta, Shuji Kitahara*, Role of microenvironment and transient tissue hypoxia in regeneration of the endometrium, J Tokyo Wom Med Univ. 89: E110-E117, 2019*Corresponding author |
2018 |
Nakamura-Ishizu A, Matsumura T, Stumpf PS, Umemoto T, Takizawa H, Takihara Y, O'Neil A, Majeed ABBA, MacArthur BD, Suda T. Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation. Cell Rep. 2018 Nov 13;25(7):1772-1785.e6.
Umemoto T, Hashimoto M, Matsumura T, Nakamura-Ishizu A, Suda T. Ca2+-mitochondria axis drives cell division in hematopoietic stem cells. J Exp Med. 2018 Jun 26. Shiozaki H, Nakamura-Ishizu A, Suda T. Ageing of hematopoietic stem cells. Rinsho Ketsueki. 2018;59(1):3-12. doi: 10.11406/rinketsu.59.3. Shuji Kitahara, Yasuhiro Suzuki, Taichi Ezaki, How immunotherapy and targeted therapy are changing gastrointestinal cancer treatment. Med Res Arch. 2018: Nov; 6(11); 1-14 Sen Li, Wende Li, Chi-Ho Leung, Shuji Kitahara, Yujiao Liu, Sebastian Klein, Dai Fukumura, Leo E Gerweck, Jay S Loeffle, Rakesh K Jain, Dan G Duda and Peigen Huang, Combing the Angiotensin Receptor Blocker Losartan and the CXCR4 Inhibitor AMD3100 Increases the Efficacy of Radiotherapy in a Metastatic Osteosarcoma Mouse Model, J Cancer Sci Ther. 2018: 10(11), 358-365 Ethel R. Pereira, Dmitriy Kedrin, Giorgio Seano, Olivia Gautier, Eelco F.J. Meijer, Dennis Jones, Shan-Min Chin, Shuji Kitahara, Jonathan Chang, Elizabeth Beech, Han-Sin Jeong, Michael C. Carroll, Alphonse G. Taghian , Timothy P. Padera. Lymph node metastases in mice can exit the node, invade local blood vessels, and colonize distant organs, Science. 2018: Mar 23;359(6382):1403-1407 Nakanishi H, Morikawa S, Kitahara S, Yoshii A, Uchiyama A, Kusuda, S, Ezaki T. Morphological characterization of the mechanism for pulmonary microvascular disease in bronchopulmonary dysplasia caused by hyperoxia in newborn mice. Med Mol Morphol. 2018: Sep;51(3):166-175 |
Before2018 |
Thiet M. Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim, Sue-Anne E. S. Toh, Toshio Suda, David L. Silver, Markus R. Wenk & Long N. Nguyen. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Nature 550, 524–528. 26 Oct 2017
Umemoto T*, Matsuzaki Y, Shiratsuchi Y, Hashimoto M, Yoshimoto T, Nakamura-Ishizu A, Petrich B, Yamato M and Suda T*., Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells., EMBO J, 2017 Suzuki Y, Kitahara S, Suematsu T, Oshima M, Sato Y. Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts, Cancer Sci. 2017: Dec;108(12):2342-2351 Yunching Chen, Ya-Chi Liu, Yun-Chieh Sung, Rakesh R. Ramjiawan, Ts-Ting Lin, Chih-Chun Chang, Kuo-Shyang Jeng, Chiung-Fang Chang, Chun-Hung Liu, Dong-Yu Gao, FuFei Hsu, Annique M. Duyverman, Shuji Kitahara, Peigen Huang, Simona Dima, Irinel Popescu, Keith T. Flaherty, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Cyril H. Benes, and Dan G. Duda. Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors, Sci Rep. 2017; 9;7:44123. Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan W, Suda T, Keller J. Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. Stem Cells. 2016 Apr;34(4):1068-82. Jia X, Kitahara S, Ezaki T. Immunohistochemical Characterization of the Endolymphatic System in the Inner Ear of Mice. Journal of Tokyo Women's Medical University. 2016; 86 (6): 223-233. Kitahara S, Desaki J, Yoshii A, Matsui A, Ezaki T. Fine structure study of the partial remodeling of capillary network in the extensor digitorum longus muscle of the normal adult rat. Microscope. 2016; 65 (6): 508-516. Kitahara S, Matsui A, Yoshii A, Kuwahara Y, Nishio M, Saeki K, Ezaki T. Endothelial Cell Transplants in Tumors Restore Normal Vasculature, Reduce Tumor Hypoxia, and Suppress Tumor Outgrowth. J Oral Bio Sci. 2016; 58 (4): 150-157 Nakamura-Ishizu A, Takubo K, Kobayashi H, Suzuki-Inoue K, Suda T. CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. J Exp Med. 2015 Nov 16;212(12):2133-46. (corresponding author) Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, Takubo K. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015 Apr 7;11(1):71-84. Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, Duda DG. CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice. Hepatology. 2015; 61(5):1591-602 Nakamura-Ishizu A, Takizawa H, Suda T. The analysis, roles and regulation of quiescence in hematopoietic stem cells. Development. 2014 Dec;141(24):4656-66. (corresponding author) Nakamura-Ishizu A, Takubo K, Fujioka M, Suda T. Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin. Biochem Biophys Res Commun. 2014 Nov 14;454(2):353-7. (corresponding author) Nakamura-Ishizu A, Suda T. Not merely quiescent: telomeres in quiescent HSCs. Blood. 2014 Nov 20;124(22):3179-80. Nakamura-Ishizu A, Suda T. Aging of the hematopoietic stem cells niche. Int J Hematol. 2014 Oct;100(4):317-25. Review. Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T. The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells. Blood. 2014 Apr 17;123(16):2540-9. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS One. 2014; 9(9):e104728 Yoshii A, Kitahara S, Ueta H, Matsuno K, Ezaki T. Role of uterine contraction in regeneration of the murine postpartum endometrium. Biol Reprod. 2014 Aug; 91(2):32. Kitahara S, Suzuki Y, Morishima M, Yoshii A, Kikuta S, Shimizu K, Morikawa S, Sato Y, Ezaki T. Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis. Mol Cancer. 2014; 13(1):99. Kuwahara Y, Mori M, Kitahara S, Fukumoto M, Ezaki T, Mori S, Echigo C, Fukumoto M: Targeting of tumor endothelial cells combining 2 Gy/day of X-ray with Everolimus is the effective modality for overcoming clinically relevant radioresistant tumors. Cancer Med. 3 (2): 310-21, 2014. Momoki Y, Kitahara S*, Kuwahara K, Sasaki R, Ando T: Establishment of a normalized revascularization mouse model using tumor transplantation. J Oral Maxillofac Surg Med Pathol. 26 (1): 80-88, 2014. *Corresponding author June-Won Cheong*, Ayako Nakamura-Ishizu*, Eriko Nitta and Toshio Suda. Chapter 4: Hematopoietic Stem Cell Aging and Oxidative Stress. Stem Cells: From Basic Research to Therapy, Volume 1. CRC Press 2013 *Equal contribution. Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013 Jan 3;12(1):49-61. Nakamura-Ishizu A, Suda T. Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches. BBA-General Subjects Feb;1830(2):2404-9. 2013. Shimizu K, Asakura M, Shinga J, Sato Y, Kitahara S, Hoshino K, Kaisho T, Schoenberger SP, Ezaki T, Fujii S: Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction. J Immunol. 190: 5609-19, 2013. Okuno Y, Nakamura-Ishizu A, Otsu K, Suda T, Kubota Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat. Med. 18 1208-1216. 2012. Nakamura-Ishizu, A., Okuno, Y., Omatsu, Y., Okabe, K., Morimoto, J., Uede, T., Nagasawa, T, Suda, T., and Kubota, Y.. Extracellular matrix protein Tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood Jun 7;119(23):5429-37 2012 Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol. Mar 1;363(1):106-14. 2012. Iriuchishima H., Takubo K., Miyakawa Y., Nakamura-Ishizu A., Miyauchi Y., Fujita N., Miyamoto K., Miyamoto T., Ikeda E., Kizaki M., Nojima Y., Suda T. Neovascular niche for human myeloma cells in immunodeficient mouse bone. PLoS One., 7(2) e30557, 2012. Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K: Tumor-Drived Microvesicles Induce Proangiogenic Phenotype in Endothelial Cells via Endocytosis. PLoS One. 7: e34045, 2012. Nakamura-Ishizu, A. Kubota Y.,Suda T. Tenascin-C is a crucial component of the bone marrow microenvironment during hematopoietic reconstitution after myeloablation. Exp. Hematol., 39(8) Supplement 1, S35, 2011. Nakamura-Ishizu, A., Morikawa S., Shimizu K. and Ezaki T. Recruited peripheral blood monocytes participate in the liver extramedullary hematopoietic milieu. Arch Histol Cytol. Vol.73 (3):127-137 (2010/2011) Kubota, Y., Takubo K, Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. and Suda, T. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J. Exp. Med. 2011, 208(5), 949-960. Okuno, Y., Nakamura-Ishizu, A., Kishi, K., Suda, T. and Kubota, Y. Bone marrow-derived cells serve as pro-angiogenic macrophages but not endothelial cells in wound healing. Blood 117:5264-72, 2011. Shimizu, R., Okabe, K., Kubota, Y., Nakamura-Ishizu, A., Nakajima, H. and *Kishi, K. Sphere formation restores and confers hair inducing capacity in cultured mesenchymal cells. Exp. Dermatol. Aug;20(8):679-81 2011. Kitahara S, Morikawa S, Shimizu K, Abe H, Ezaki T: Alteration of angiogenic patterns on B16BL6 melanoma development promoted in Matrigel. Med Mol Morphol. 43: 26-36, 2010. Nakamura-Ishizu, A., Morikawa, S., Shimizu, K., and Ezaki, T. Characterization of sinusoidal endothelial cells of the liver and bone marrow using an intravital lectin injection method. J Mol Histol, 2008, 39, 471-9. Shimizu K, Morikawa S, Kitahara S, Ezaki T: Local lymphogenic migration pathway in normal mouse spleen. Cell Tissue Res. 338: 423-432, 2009. |
東京女子医科大学
解剖学(顕微解剖・形態形成学分野) 〒162-8666 東京都新宿区河田町8-1 Tel.(FAX.) 03-5269-7407 |